Pulse Pressure, Aortic Reactivity, and Endothelium Dysfunction in Old Hypertensive Rats
نویسندگان
چکیده
منابع مشابه
Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats.
The reactivity of old hypertensive rat aortas has not been investigated in relation to each phenotype of the blood pressure curve, mean arterial pressure (MAP), and pulse pressure (PP). Aortic reactivities from 3- to 78-week-old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were studied with the use of organ chambers and invasive blood pressure, carotid diameter, and histomo...
متن کاملPulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats.
In rats, removal of the carotid arterial or abdominal aortic endothelium results in an acute increase of diameter and compliance. In humans, acute local administration of a specific NO synthase inhibitor increases radial artery compliance but not the diameter. The purpose of this review is to determine whether in spontaneously hypertensive rats (SHR), a cause-and-effect relationship may be obse...
متن کاملNitric oxide and endothelium-dependent effect of Tribulus terrestris feeding on aortic reactivity of streptozotocin-diabetic rats
Background and Objective: Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of Tribulus terrestris (TT) feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats and some underlying mechanisms were investigated. Materials and Methods: Male diabetic rats receive...
متن کاملPulse pressure and endothelial dysfunction in never-treated hypertensive patients.
OBJECTIVES This study sought to investigate whether pulse pressure (PP) is associated with endothelium-dependent vasodilation in a group of never-treated hypertensives. BACKGROUND Pulse pressure represents a well-established independent predictor for cardiovascular morbidity and mortality. Forearm endothelial dysfunction, defined as impaired vasodilating response to acetylcholine (ACh), may b...
متن کاملAortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats.
In humans, increased body weight and arterial stiffness are significantly associated, independently of blood pressure (BP) level. The finding was never investigated in rodents devoid of metabolic disorders as spontaneously hypertensive rats (SHR). Using simultaneous catheterization of proximal and distal aorta, we measured body weight, intra-arterial BP, heart rate and their variability (spectr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.37.2.313